Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to dentin.

Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to dentin.


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نویسندگان: محمد اسماعیل ابراهیمی چهارم , مهدی عابد کهنمویی , محمود بهاری , حامد همیشه کار

کلمات کلیدی: N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide, Matrix metalloproteinase inhibitors, Dentin, Extracellular matrix, Luting agents, Dental Bonding.

نشریه: 19695 , 3 , 9 , 2017

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نویسنده ثبت کننده مقاله محمود بهاری
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه دانشکده دندانپزشکی,مرکز تحقیقات لثه و دندان
کد مقاله 61421
عنوان فارسی مقاله Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to dentin.
عنوان لاتین مقاله Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to dentin.
ناشر 5
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح دو – PubMed
آدرس لینک مقاله/ همایش در شبکه اینترنت https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347294/pdf/jced-9-e431.pdf

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Search term Clear input Advanced Journal list Help Journal ListJ Clin Exp Dentv.9(3); 2017 MarPMC5347294 Logo of jced J Clin Exp Dent. 2017 Mar; 9(3): e431–e436. Published online 2017 Mar 1. doi: 10.4317/jced.53486 PMCID: PMC5347294 Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to dentin Mohammad-Esmaeel Ebrahimi-Chaharom,1,2 Mehdi Abed-Kahnamoui,2 Mahmoud Bahari,corresponding author1,3 Hamed Hamishehkar,4 and Mahya Gharouni5 Author information ► Article notes ► Copyright and License information ► Go to: Abstract Background Considering the probability of chemical and enzymatic reactions between matrix metalloproteinases (MMPs) in the dentin structure and their specific inhibitors, the aim of the present study was to evaluate the effect of different concentrations of specific inhibitor of MMPs (galardin) on the shear bond strength of self-adhesive resin cements to dentin. Material and Methods Forty-eight sound human premolars were mounted in self-cured acrylic resin after removal of the enamel on the buccal and lingual surfaces. The dentin surfaces achieved were polished and prepared with 600-grit silicon carbide paper. The samples were divided into 3 groups (n=16) based on the concentration of galardin used (with no galardin, galardin at a high concentration and galardin at a low concentration). In addition, 96 composite resin blocks, measuring 3 mm in height and diameter, were prepared. The composite resin blocks were bonded to the buccal and lingual surface dentin with Rely-X Unicem (RXC) and Speed CEM (SPC) self-adhesive resin cements, respectively, according to manufacturers’ instructions. After 24 hours of storage in distilled water at 37°C, the shear bond strength values were determined in MPa and fracture modes were evaluated under a stereomicroscope. Data were analyzed with two-way ANOVA and post-hoc Bonferroni test (α=0.05). Results The shear bond strength of galardin at high concentration was significantly higher than that in the control group and galardin at a low concentrations (P<0.001). In addition, galardin at a low concentration exhibited higher shear bond strength compared to the control group (P=0.005). Furthermore, higher shear bond strength values were reported with the use of RXC compared to SPC (P<0.001). Conclusions Irrigation with galardin increased the shear bond strength of self-adhesive resin cements to dentin and this increase had a direct relationship with the concentration of galardin in the solution.

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نویسنده نفر چندم مقاله
محمد اسماعیل ابراهیمی چهارماول
مهدی عابد کهنموییدوم
محمود بهاریسوم
حامد همیشه کارچهارم

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