Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems
Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems
نویسندگان: رویا صالحی قره ورن , ابوالفضل اکبرزاده , سودابه داوران
کلمات کلیدی: Nanofibers . Doxorubicin . Electrospinning .Biodegradable polymers . Korsmeyer–Peppasmodel .Fluorescence
نشریه: 0 , - , - , 2017
| نویسنده ثبت کننده مقاله |
ابوالفضل اکبرزاده |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده علوم نوین پزشکی |
| کد مقاله |
61209 |
| عنوان فارسی مقاله |
Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems |
| عنوان لاتین مقاله |
Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems |
| ناشر |
4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
BioNanoScience |
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
https://link.springer.com/article/10.1007/s12668-017-0421-3 |
| Through the present research, for the first time, doxorubicin hydrochloride (DOX)-loaded poly (ε- caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers were obtained by blending electrospinning method. The physicochemical characteristics
of the DOX/PCEC nanofibers were fully evaluated. Nanofibers had homogeneous morphology with mean diameters
ranging from 80 to 300 nm. The drug releasing behavior showed the faster release rate by increasing the drug content in
nanofibers. The in vitro release profile and release kinetics from the DOX/PCEC nanofibers confirmed that the release
profile followed Korsmeyer–Peppas model suggesting a Fickian diffusion as a major drug release mechanism |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 54-Bakhtiari,BioNanoSci,2017.pdf | 1396/05/22 | 3140962 | دانلود |