چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | میترا جلوه گری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 61197 |
| عنوان فارسی مقاله | Novel Penta Block Copolymers: Thermosensitive Polymeric Micelles Self-Assembled as Ocular Drug Delivery Systems |
| عنوان لاتین مقاله | Novel Penta Block Copolymers: Thermosensitive Polymeric Micelles Self-Assembled as Ocular Drug Delivery Systems |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Review Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.scopus.com/record/display.uri?eid=2-s2.0-85017549660&origin=resultslist&sort=plf-f&src=s&st1=salehi&st2=roya&nlo=1&n |
| Many studies have focused on how drugs are formulated in the sol state at room temperature leading to the formation of in situ gel at eye temperature to provide a controlled drug release. Stimuli-responsive block copolymer hydrogels possess several advantages including uncomplicated drug formulation and ease of application, no organic solvent, protective environment for drugs, site-specificity, prolonged and localized drug delivery, lower systemic toxicity, and capability to deliver both hydrophobic and hydrophilic drugs. Self-assembling block copolymers (such as diblock, triblock, and pentablock copolymers) with large solubility variation between hydrophilic and hydrophobic segments are capable of making temperature-dependent micellar assembles, and with further increase in the temperature, of jellifying due to micellar aggregation. In general, molecular weight, hydrophobicity, and block arrangement have a significant effect on polymer crystallinity, micelle size, and in vitro drug release profile. The limitations of creature triblock copolymers as initial burst release can be largely avoided using micelles made of pentablock copolymers. Moreover, formulations based on pentablock copolymers can sustain drug release for a longer time. The present study aims to provide a concise overview of the initial and recent progresses in the design of hydrogel-based ocular drug delivery systems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| میترا اعلمی میلانی | اول |
| پروین ذاکری میلانی | دوم |
| هادی ولیزاده | سوم |
| سارا سلاطین | پنجم |
| میترا جلوه گری | ششم |
| رویا صالحی قره ورن | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 44-APB-Jelvehgari, 2017.pdf | 1396/05/21 | 1372403 | دانلود |
