Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions
Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions
نویسندگان: فرناز منجم زاده , محمد رضا سیاهی شادباد , هادی ولیزاده , محبوب نعمتی , فرانک قادری
کلمات کلیدی: Hydrochlorothiazide/lactose/Maillard reaction. Hydrochlorothiazide/lactose/interaction/
kinetic parameters. High Performance Liquid Chromatography (HPLC)/kinetic parameters study.
نشریه: 5246 , 4 , 52 , 2016
| نویسنده ثبت کننده مقاله |
فرناز منجم زاده |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده داروسازی |
| کد مقاله |
61180 |
| عنوان فارسی مقاله |
Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions |
| عنوان لاتین مقاله |
Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://www.scielo.br/pdf/bjps/v52n4/2175-9790-bjps-52-04-00709.pdf |
| The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated
in pharmaceutical formulations. In this study, the activation energy of – hydrohlorothiazide and lactose
interaction in the liquid state was ascertained under basic and neutral conditions. Conventional isothermal
High Performance Liquid Chromatography (HPLC) technique was employed to ascertain the kinetic
parameters using Arrhenius method. Results: The activation energy obtained was 82.43 and 100.28
kJ/mol under basic and neutral conditions, respectively. Consequently, it can be inferred that Maillard
reaction is significantly affected by pH, which can be used as a control factor whenever the reaction
potentially occurs. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Brazilian HCTZ.pdf | 1396/05/18 | 438353 | دانلود |
| Ghaderi sabt.doc | 1396/05/18 | 86016 | دانلود |