The odontogenic differentiation of human dental pulp stem cells on hydroxyapatite-coated biodegradable nanofibrous scaffolds
The odontogenic differentiation of human dental pulp stem cells on hydroxyapatite-coated biodegradable nanofibrous scaffolds
نویسندگان: فاطمه اصغری , رویا صالحی قره ورن , مرضیه آقازاده , عفت علیزاده , خسرو ادیب کیا , محمد سمیعی , ابوالفضل اکبرزاده , نگار عیاسی اول , سودابه داوران
کلمات کلیدی: Dental pulp stem cells;differentiation; nanofibers;odontogenic; regenerative medicine; scaffold; tissue engineering
نشریه: 0 , 14 , 65 , 2016
| نویسنده ثبت کننده مقاله |
سودابه داوران |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده علوم نوین پزشکی |
| کد مقاله |
61172 |
| عنوان فارسی مقاله |
The odontogenic differentiation of human dental pulp stem cells on hydroxyapatite-coated biodegradable nanofibrous scaffolds |
| عنوان لاتین مقاله |
The odontogenic differentiation of human dental pulp stem cells on hydroxyapatite-coated biodegradable nanofibrous scaffolds |
| ناشر |
9 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS |
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://dx.doi.org/10.1080/00914037.2016.1163564 |
| The authors aimed to design nanofibrous (NF) scaffolds that facilitate odontogenic and osteogenic
differentiation of human dental pulp-derived mesenchymal stem cells (DPSCs) in vitro. For this purpose,
hydroxyapatite (HA)–loaded poly (L-lactic acid)/poly ('-caprolactone) (PLLA:PCL 2;1) blend NFs were
prepared using the electrospinning method. Alizarin red activity and cell viability were evaluated by MTT
assay, and SEM revealed the proliferation properties of NF scaffolds. QRT-PCR results demonstrated that
HA-loaded PLLA/PCL can lead to osteoblast/odontoblast differentiation in DPSCs through the upregulation
of related genes, thus indicating that electrospun biodegradable PCL/PLA/HA has remarkable
prospects as scaffolds for bone and tooth tissue engineering. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 33-Int.J.Polym.Mater, Asghari, 2016.pdf | 1396/05/18 | 1295892 | دانلود |