چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد رحمتی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 61142 |
| عنوان فارسی مقاله | The comparison between effects of free curcumin and curcumin loaded PLGA-PEG on telomerase and TRF1 expressions in calu-6 lung cancer cell line |
| عنوان لاتین مقاله | The comparison between effects of free curcumin and curcumin loaded PLGA-PEG on telomerase and TRF1 expressions in calu-6 lung cancer cell line |
| ناشر | 10 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | International Journal of Biosciences |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح چهار – Index Copernicus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://dx.doi.org/10.12692/ijb/4.10.134-145 |
| lung cancer is the most common cancer in men still now. Telomerase is responsible for cancerous cells immortality and is a suitable target for cancer therapy. TRF1 is a modulator for telomerase activity. It is necessary to find more efficient and safer anticancer drugs. Curcumin is a natural polyphenol which has many anticancer effects but it has hydrophobic structure and low solubility in water. PLGA-PEG nanoparticles was used to comprise effects of free curcumin and curcumin loaded PLGAPEG on telomerase and TRF1 expressions in lung cancer cell line. 1H NMR, FT-IR and SEM confirmed PLGA-PEG structure and curcumin loading on it. Then, cytotoxic effects of free curcumin and curcumin loaded PLGA-PEG determined by MTT assay. mRNA expression levels of hTERT and TRF1 was determined by Real-time PCR. MTT assay data analysis indicated that curcumin cytotoxicity is dose and time-dependent. Curcumin loaded nanoparticles showed IC50 values in lower concentration in comparison to free curcumin. Curcumin loaded PLGA-PEG decreased hTERT expression and increased TRF1 expression more than pure curcumin. Our study demonstrates curcumin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight lung cancer |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | ششم |
| نصرت اله ضرغامی | هفتم |
| مسعود دارابی امین | هشتم |
| ابوالفضل اکبرزاده | نهم |
| محمد رحمتی | دهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 20-IJB,2014,Taheri.pdf | 1396/05/16 | 782217 | دانلود |
