Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs
Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs
نویسندگان: رویا صالحی قره ورن , عفت علیزاده , حسین صمدی کفیل , مهرداد مهکام
کلمات کلیدی: Antibacterial polymers; combination therapy; dual anticancer drug; sustained release; stimuli responsive; nanocomposite
نشریه: 3429 , - , - , 2016
| نویسنده ثبت کننده مقاله |
رویا صالحی قره ورن |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده علوم نوین پزشکی |
| کد مقاله |
61111 |
| عنوان فارسی مقاله |
Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs |
| عنوان لاتین مقاله |
Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs |
| ناشر |
6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://dx.doi.org/10.1080/21691401.2016.1260576 |
| Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized
nanocarrier was characterized by FTIR, 1H NMR, thermogravimetric analysis (TGA), and FESEM-EDX.
Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values.
Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both
drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient
anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests. It was concluded
that this novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed
spontaneously, representing more efficient drug delivery system in nanomedicine |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 37-Zakerzadeh, Artificial cells, 2016.pdf | 1396/05/12 | 1647679 | دانلود |