چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | رویا صالحی قره ورن |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 61110 |
| عنوان فارسی مقاله | Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy |
| عنوان لاتین مقاله | Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy |
| ناشر | 3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.scopus.com/record/display.uri?eid=2-s2.0-85012996360&origin=resultslist&sort=plf-f&src=s&st1=Salehi&st2=roya&nlo=1&n |
| A novel antibacterial clay/polymer nanocomposite with average particle size of 20–40 nmand two cationic compartments in polymer was synthesized via ion exchange. The structure of the nanocompositeswas characterized by XRD, FT-IR, TG-DTA, and SEM. Thismultifunctional nanocompositewas used for dual drug delivery of anticancer drug methotrexate (MTX) and an antibacterial agent ciprofloxacin (CIP) with encapsulation efficiency of N90% for both drugs. The in vitro antimicrobial activity of the clay/polymer nanocomposites was studied against Escherichia coli and Pseudomonas aeruginosa bacteria by a well diffusion method. The nanocomposite showed good or moderate antimicrobial activities. However, CIP loaded nanocomposites showed enhanced antimicrobial activity in comparison to free CIP. The potential antitumoral activity of this clay/polymer nanocomposite system was evaluated againstMCF7 cell lines by MTT assay and cell cycle studies. The cytotoxicity studies demonstrated enhanced cytotoxicity of developed MTX loaded nanocomposite in comparison to free MTX. Cell cycle study showed that MTX-loaded nanocomposite caused S-phased arrest in MCF-7 cells compared to control nontreated cells (P b 0.001). Therefore, dual drug-loaded antibacterial nanocomposite has the potential to be used for cancer therapy |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | دوم |
| مهرداد مهکام | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 45-Applied Clay Science-Bazmi,2017.pdf | 1396/05/12 | 2655963 | دانلود |
