چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سوسن کلاهی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 61077 |
| عنوان فارسی مقاله | Osteoprotegerin (OPG) Levels, Total Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand (Total sRANKL), and OPG/RANKL Ratio in Patients With Rheumatoid Arteritis |
| عنوان لاتین مقاله | Osteoprotegerin (OPG) Levels, Total Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand (Total sRANKL), and OPG/RANKL Ratio in Patients With Rheumatoid Arteritis |
| ناشر | 8 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | Rheum. Res |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح چهار – SID/Iranmedex/Magiran |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | Webpage: http://rheumres.org |
| Rheumatoid arthritis (RA) is one of most important collagen vascular diseases. It has an unknown origin. The aim of this study was to evaluate circulating levels of osteoprotegerin (OPG), total soluble receptor activator of nuclear factor-Kappa B ligand (total sRANKL), and RANKL/OPG ratio in patients with RA. Forty-five females with RA, who fulfilled the American college of rheumatology (ACR) criteria for RA were included in this cross-sectional study. The overall disease activity was evaluated by the disease activity score based on 28 joint counts (DAS-28). The OPG and sRANKL were measured by the enzyme-linked immunosorbent assays (ELISA). The levels of C-reactive protein (CRP) were measured by ELISA.We used Pearson’s correlation for our comparisons. There was no statistically significant difference between the levels of CRP, OPG, sRANKL and RANKL/OPG ratio in terms of DAS-28 grades in our patients. No significant correlation was found between the serum levels of OPG and DAS-28 (P= 0.525), duration of the disease (P= 0.884), Z-score of the femur (P= 0.546) and Zscore of the spine (P= 0.492), T-score of the femur (P= 0.137) and T-score of the spine (P= 0.821) in the patient group. No significant correlations were found between sRANKL levels with DAS-28 (0.919), Z-score of the femur (P= 0.971), Z-score of the spine (P= 0.832) and T-score of the femur (P = 0170) in the studied groups. Our study showed that there was no significant correlation between CRP, OPG, sRANKL and RANKL/OPG ratio in DAS-28 grading of our patients. For this reason they will not be used for evaluating disease activity. However, there was a significant difference between case and control groups except for sRANKL (pg/mL) |
| نویسنده | نفر چندم مقاله |
|---|---|
| سوسن کلاهی | اول |
| امیر قربانی حق جو | دوم |
| نادره رشتچی زاده | سوم |
| علیرضا خبازی اسکویی | چهارم |
| مهرزاد حاج علیلوی بناب | پنجم |
| حمید نوشاد عباسپور | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RR_Volume 2_Issue 1_Pages 23-29.pdf | 1396/05/05 | 568757 | دانلود |
