Procognitive Biotransformed Products of Nicotine

مجریان: سعید صدیق اعتقاد

خلاصه روش اجرا: We electronically will search Embase, MEDLINE via PubMed, ProQuest (for thesis) and SCOPUS for studies that had investigated the effects of nicotine metabolites on cognitive impairment using “nicotine metabolite”, “cotinine”, “nornicotine”, “norcotinine”, “nor-nicotine”, “nor-cotinine”, “cognition”, “memory”, and “learning” as follows: [(memory) OR (learning) OR (cognition)] AND [(cotinine) OR (nicotine metabolite) OR (nornicotine) OR (nor-nicotine) OR (norcotinine) OR (nor-cotinine)]. Two investigators independently will screen title, abstract and where necessary full text, based on the inclusion and exclusion criteria. Where there will be disagreements, the third investigator resolved the controversy. There will no date and species restriction in our search and the study will limit to English and original articles. We will include all studies reported the effects of nicotine metabolites (i.e. cotinine, nornicotine, and norcotinine) on the cognitive function. The primary outcome of this study is to find biotransformed products of nicotine in the brain, and the secondary outcomes are to investigate their impacts on the cognitive function and find the mechanisms behind. We will exclude every study which assessed the effects of smoking, smoke, cigar, or tobacco on the cognitive abilities. We also will exclude studies which evaluated nicotine (and not its metabolites) effects on the cognitive impairment.