چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | وحید شفیعی ایران نژاد |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات بیوتکنولوژی(زیست فناوری) |
| کد مقاله | 60881 |
| عنوان فارسی مقاله | نانوسلولز کریستالی شاخه دار توسط تریس(2-آمینواتیل)آمین به عنوان دارورسان جدید و زیست سازگار برای دارورسانی داروی ضدسرطان متوتروکسات |
| عنوان لاتین مقاله | Biocompatible magnetic tris(2-aminoethyl)amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | New Journal of Chemistry (NJC) |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://pubs.rsc.org/en/content/articlelanding/2017/nj/c6nj03332f#!divAbstract |
| In cancer therapy, biocompatible and smart nanocarriers are the most important types of therapeutic agents. In this paper, a novel magnetic nanocarrier was fabricated and investigated for controlled release of methotrexate (MTX). A magnetic nanocarrier was synthesized by decoration of Fe3O4 nanoparticles using biocompatible tris(2-aminoethyl)amine functionalized nanocrystalline cellulose (AMFC). AMFC coated magnetic nanoparticles (AMFC@MNPs) were characterized by various technologies including FTIR, SEM-EDX, VSM, XRD, DLS and zeta potential analysis. MTX was loaded on the nanocarrier at physiological pH (7.4) due to the hydrogen bonding and electrostatic interactions between cationic amino groups on the nanocarrier and anionic carboxylate groups of MTX molecules. The MTX release ability of the synthesized nanocarrier was proved through the comparison of in vitro drug release under simulated physiological and tumor tissue conditions. The cumulative release of the MTX-loaded nanocarrier was pH dependent with a superior release rate at pH 5.4. The results of MTT assay and DAPI staining showed that the MTX-loaded nanocarrier revealed a high cytotoxicity in the MCF7 breast cancer cell line after 48 h incubation. Also, the results of cytotoxicity and hemolysis assays have shown that there are negligible toxicity and hemolytic effects of AMFC@MNPs at high concentrations. Therefore, it was concluded that our nanocarrier has many promising advantages as an efficient carrier for the targeted MTX delivery to the cancer cells. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدی رحیمی حسین آباد | اول |
| رویا صالحی قره ورن | پنجم |
| وحید شفیعی ایران نژاد | هفتم |
| بهمن یوسفی | ششم |
| سلمان شجاعی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| authorreprint cellulose.pdf | 1396/03/28 | 6886484 | دانلود |
