چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سعید صدیق اعتقاد |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات علوم اعصاب |
| کد مقاله | 60878 |
| عنوان فارسی مقاله | The Effects of Rosa canina Fruit Hydro alcoholic Extract on Oxidative Stress, Total Antioxidant Capacity and Haematological Parameters in Diabetic Mice |
| عنوان لاتین مقاله | The Effects of Rosa canina Fruit Hydro alcoholic Extract on Oxidative Stress, Total Antioxidant Capacity and Haematological Parameters in Diabetic Mice |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://jkmu.kmu.ac.ir/article_46778_5b7ac7c831c51953add75ff421d195ff.pdf |
| Diabetes is a metabolic disorder with adverse effects on haematological parameters level, oxidative stress and antioxidant defence system. This study aimed to investigate the effects of Rosa canina (RC) fruit hydro alcoholic extract on oxidative stress, total antioxidant capacity (TAC) and haematological parameters in diabetic mice. In this study, 96 mice were randomly divided into the four groups (n=24). The control and diabetic groups received normal saline (p.o., 0.2 ml). Also, RC and treatment (diabetes+RC) groups received RC hydro alcoholic extract (p.o., 500 mg/kg). Diabetes was induced by a single dose of streptozotocin (i.p., 200 mg/kg).The study parameters were evaluated on day 10, 20, and 30 after the initiation of experiments. In the second and third sampling days, WBCs, lymphocytes, haemoglobin, RBC, MCV, MCHC, platelets, TAC and weight had a significant reduction (p<0.01) in the diabetic group in comparison to the control group. However, granulocytes, RDW, malondialdehyde (MDA) and glucose in the diabetic group significantly increased compared with the control group (p<0.01). Administration of the extract in the diabetic group significantly increased hemoglobin, MCV, MCHC, platelets, RBC, serum TAC and resulted in significant reduction in RDW and MDA levels in comparison to normal saline received diabetic animals (p<0.01). Based on our results, RC fruit extract has a regulatory role in controlling oxidative stress, serum TAC and hematologic factors in mice model of diabetes. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید صدیق اعتقاد | دوم |
| جواد محمودی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| JKMU_Volume 24_Issue 2_Pages 132-140.pdf | 1396/03/28 | 2264358 | دانلود |
