چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سپیده زنونی واحد |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کلیه |
| کد مقاله | 60844 |
| عنوان فارسی مقاله | microRNA-148a, a potentially reliable biomarker associated with renal allograft dysfunction |
| عنوان لاتین مقاله | microRNA-148a, a potentially reliable biomarker associated with renal allograft dysfunction |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 16th International Congress of Nephrology, Dialysis, and Transplantation, 3rd International Congress of Organ Transplantation |
| نوع کنگره / همایش | سخنرانی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | شیراز |
| سال انتشار/ ارائه شمسی | 1396 |
| سال انتشار/ارائه میلادی | 2017 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1396/02/26 الی 1396/02/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.ijkd.org/index.php/ijkd/article/viewFile/3391/917 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده زنونی واحد | اول |
| یلدا رهبرسعادت | دوم |
| محمد رضا اردلان | سوم |
| ناصر صمدی | چهارم |
| یداله امیدی | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Transplantation, microRNAs |
| خلاصه مقاله | Background. Despite improvement in short term graft outcome, most of renal recipients will develop chronic allograft dysfunction (CAD), the foremost cause of renal graft loss worldwide. So far, CAD is diagnosed by renal biopsy when irreversible damages occur in the graft. Due to invasive nature of histological study, novel non-invasive biomarkers are required in biomedicine. Here, the researchers sought to determine the significance of circulating miR-148a expression levels in anticipating the renal graft function. Methods. Circulating miRNAs were isolated from 53 plasma samples of recipients with biopsy proven interstitial fibrosis and tubular atrophy (IFTA) and recipients with stable graft function (SGF) and 15 healthy controls as controls. Expression levels of miR-148a and miR-433 were evaluated by real-time quantitative-PCR (q-PCR) and correlated with clinical and histological parameters. Results. miR-148a expression significantly down-regulated in recipients with IFTA (P < 0.001). A diminished level of miR-148a was even lower in recipients with IFTA garde III. miR-148a levels indicated a significant correlation with serum creatinine levels (r = 0.451, P = 0.021) and inverse strong correlation with eGFR (r = -0.520, P = 0.006). miR-148a expression levels could discriminate IFTA in recipients with an area under the curve (AUC) of 0.89 (P < 0.001) with 97% sensitivity and 72% specificity. Conclusions. Plasma cell-free miR-148a correlated with renal function and histological grades; therefore, its level should be further investigated as a novel non-invasive molecular biomarker of progression to fibrosis and tubular atrophy in renal transplant recipients. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Shiraz abstracts-2017.pdf | 1396/03/23 | 1206777 | دانلود |
| 1.png | 1396/03/23 | 835401 | دانلود |
| miR-148.docx | 1396/04/12 | 16051 | دانلود |
