چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | نادره رشتچی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60713 |
| عنوان فارسی مقاله | ارزیابی نسبت sRANKL به استئوپروتگرین در زمان حاملگی : مطالعه کلینیکال ترایال دوسویه کور |
| عنوان لاتین مقاله | Effects of High and low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand / Osteoprotegerin Ratio During Pregnancy: A Randomized Double-blind Clinical Trial |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://ijph.tums.ac.ir/index.php/ijph |
| Background: Pregnancy Associated Osteoporosis (PAO) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. Soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) to Osteoprotegerin (OPG) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporosis and would be modified with folic acid supplementation. Our study was done to compare the effects of high dose (5mg/day) and low dose (0.5mg/day) folic acid in the RANKL/OPG ratio and Tumor Necrosis Factorα (TNFα) concentration during pregnancy. Methods: Forty-five pregnant women were assigned into two groups in this randomized, double-blind, clinical trial. Groups included women who took 5mg/day (group1) and who took 0.5 mg/day (group2) folic acid supplementation before pregnancy until 36th pregnancy. The biochemical variables in serum of pregnant women were measured before and at the end of the study. Results: OPG levels were significantly higher compared with the baseline value (P=0.008), although sRANKL (P<0.001), TNFα (P=0.005) and sRANKL/OPG ratio (P<0.001) reduced significantly with high dose of folic acid supplementation. A significant positive correlation was observed between the decreased RANKL and TNFα levels (r=0.451, P=0.031) at the end of study in high dose group. Conclusions: Our findings suggest that high dose of folic acid supplementation could decrease bone resorptive biomarkers and may prevent PAO in pregnant women by increasing OPG and decreasing sRANKL and TNFα. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر قربانی حق جو | دوم |
| نادره رشتچی زاده | هفتم |
| منیژه سیاح ملی | سوم |
| مریم واعظی | چهارم |
| نازیلا فتحی معروفی | اول |
| مریم بنازاده امیرخیز | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| fathi.folicacid.pdf | 1396/02/28 | 844537 | دانلود |
