چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | امیر قربانی حق جو |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60694 |
| عنوان فارسی مقاله | سطح سرمی sTWEAK وFGF-23 در بیماران همودیالیز و پیوند کلیه |
| عنوان لاتین مقاله | sTWEAK and FGF-23 levels in Hemodialysis patients and Renal Transplant Recipients |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – PubMed |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.ijotm.com/ojs/index.php/IJOTM/index |
| Objective: The aim of present study was to evaluate the changes in serum levels of fibroblast growth factor 23 (FGF-23) and soluble TNF like weak inducer of apoptosis (sTWEAK), as biomarkers of atherosclerosis, endothelial dysfunction and cardiovascular outcome in the hemodialysis (HD) patients and renal transplant recipients (RTR). Methods: Serum samples were obtained from 30 stable chronic HD patients, 30 stable RTRs and 30 normal controls. Biochemical factors, sTWEAK, FGF-23, Interlukin-6 (IL-6) were determined by standard methods. Results: Serum levels of sTWEAK in RTR were significantly higher than those in the HD patients (p=0.025) and both groups had significantly lower sTWEAK levels than controls (p=0.001 and p= 0.038 respectively). Serum levels of FGF-23 in HD patients were significantly higher than those in the RTR (p=0.001) and in both groups were higher than those in controls (p=0.001 both the cases). The mean serum level of IL-6 in HD was significantly higher than that in RTR patients(p=0.013). IL-6 levels in both groups were significantly higher than those in controls(p=0.001 and p= 0.012 respectively). Conclusion: Although our study shows that serum sTWEAK is decreased and FGF-23 is increased in HD and RTR groups comparing with control group, their direct role on atherosclerosis, endothelial dysfunction and cardiovascular outcome needs further studies in the future. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر قربانی حق جو | دوم |
| نادره رشتچی زاده | هفتم |
| جاوید صفا | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| eskandari.pdf.stweak.fgf23.pdf | 1396/02/26 | 1025306 | دانلود |
