چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | علیرضا نورآذریان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 60669 |
| عنوان فارسی مقاله | Investigation of gene expression and serum levels of PIN1 and eNOS with high blood pressure in patients with Alzheimer disease |
| عنوان لاتین مقاله | Investigation of gene expression and serum levels of PIN1 and eNOS with high blood pressure in patients with Alzheimer disease |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S0967586816309663 |
| According to evidence, Alzheimer’s disease is known as one of the most serious neurodegenerative diseases, for which hypertension has been observed to be a key risk factor. Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer’s disease sufferers. Blood samples were obtained from subjects who were divided into four groups: the control group, normotensive Alzheimer’s patients, the Alzheimer’s sufferers group with hypertension, and the healthy group with only hypertension, considering the inhibition of confounding factors. Thereafter, eNOS and PIN1 genes expression along with serum levels were studied. Based on the obtained results, a statistically significant correlation didn’t exist between serum level of PIN1 and the systolic and diastolic blood pressure, between serum level of eNOS and diastolic blood pressure in the norm tension Alzheimer’s disease patients, between serum levels of PIN1, eNOS and systolic blood pressure, and between serum eNOS and systolic and diastolic blood pressure in the patients with hypertension (p < 0.05). According to the results obtained from this study, measuring the serum levels of eNOS and Pin1 may contribute to the prognosis, prevention, and monitoring of hypertension and also to the reduction of death rates from cardiovascular diseases in Alzheimer’s disease. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسعود نیکانفر | دوم |
| فاطمه خاکی خطیبی | سوم |
| رضا رهبرقاضی | چهارم |
| سید منوچهر نورآذریان | پنجم |
| علیرضا نورآذریان | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Article.pdf | 1396/02/23 | 518732 | دانلود |
