چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد رضا اردلان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کلیه |
| کد مقاله | 60642 |
| عنوان فارسی مقاله | Differential expression of circulating miR‑21, miR‑142‑3p and miR‑155 in renal transplant recipients with impaired graft function |
| عنوان لاتین مقاله | Differential expression of circulating miR‑21, miR‑142‑3p and miR‑155 in renal transplant recipients with impaired graft function |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://link.springer.com/article/10.1007%2Fs11255-017-1602-2 |
| Background The discovery of circulating microRNAs (miRNAs), as potential noninvasive diagnostic biomarkers, has opened new avenues of research for identifying patients with chronic failure in renal transplantation. The present study aimed to investigate the expression levels of four immune-related miRNAs (miR-21, miR-31, miR-142-3p and miR-155) in plasma samples of renal recipients. Methods The plasma expression levels of the miRNAs were evaluated by quantitative real-time PCR (qPCR) in 53 renal recipients with long-term stable allograft function, SGF (N = 27), and with biopsy-proven interstitial fibrosis and tubular atrophy (IFTA) (N = 26) and also healthy controls (N = 15). The possible correlation between clinical parameters and the circulating miRNAs and the receiveroperating characteristic (ROC) analysis were performed. Results Our results showed that expression of miR-21 (p = 0.023), miR-142-3p (p = 0.048) and miR-155 (p = 0.005) was significantly upregulated in plasma samples of recipients with IFTA in comparison with SGF and healthy control groups. Concentration of miR-21 (ΔCt value) in plasma was negatively correlated with creatinine (r = −0.432, p = 0.028) and positively correlated with eGFR (r = 0.423, p = 0.031). The multivariate ROC curve analysis indicated that miR-21, miR-142-3p and miR- 155 in plasma samples could discriminate almost most of the IFTA patients (area under curve = 0.802, sensitivity= 81%, specificity = 92%). Conclusion Our data suggested that altered expression of miR-21, miR-142-3p and miR-155 in plasma samples may be associated with renal dysfunction and can be used for graft monitoring. |
| نویسنده | نفر چندم مقاله |
|---|---|
| یداله امیدی | ششم |
| ناصر صمدی | پنجم |
| محمد رضا اردلان | هفتم |
| مرتضی قوجازاده | چهارم |
| احمد پورصادق زنوزی | دوم |
| سپیده زنونی واحد | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Differential expression of circulating.pdf | 1396/03/10 | 945032 | دانلود |
