چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خسرو ادیب کیا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60637 |
| عنوان فارسی مقاله | Methylprednisolone acetate–Eudragit RS100 electrospuns: Preparation and physicochemical characterization |
| عنوان لاتین مقاله | Methylprednisolone acetate–Eudragit RS100 electrospuns: Preparation and physicochemical characterization |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.tandfonline.com/doi/full/10.3109/21691401.2014.965309 |
| Theaimofthepresentstudywastoformulatemethylprednisolone acetate -Eudragit RS100 nano,bers and nanobeads by the electrospinning method. The physicochemical characteristics of the prepared electrospuns were assessed as well. The particle size and morphology were evaluated using scanning electron microscopy. The crystallinity of the drug in the nano,bers and nanobeads obtained was also studied by X-ray crystallography and di2erential scanning calorimetry (DSC) thermograms. In addition, FT-IR spectroscopy was applied to investigate any possible chemical interaction between the drug and carrier during the preparation process. The drug release kinetics were considered, to predict the release mechanism. Increasing the concentration of the injected solution resulted in the production of more nano,bers and less nanobeads, with the particle size rangingfrom100 to500nm.Thedrugcrystallinitywasdecreased during the electrospinning process; however, no interaction between drug and polymer was observed. The electrospuns showed faster drug release pattern compared to the pure drug. The release data were best ,tted to theWeibull model, in which the corresponding shape factor values of the model were less than 0.75 indicating the di2usion mechanism of drug release. In conclusion, electrospinning could be considered as a simple and cost e2ective method for fabricating the drug: polymer nano,bers and nanobeads. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خسرو ادیب کیا | دوم |
| محمد برزگر جلالی | چهارم |
| علیرضا پرویزپور | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Methylprednisolone acetate -Eudragit RS100 nanofibers and nanobeads (ACNN).pdf | 1396/02/19 | 975157 | دانلود |
