چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید منوچهر نورآذریان | اول |
| علیرضا نورآذریان | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Type 1 diabetes Mellitus (T1DM) is an autoimmune disease and Type 2 diabetes Mellitus (T2DM) is multifactorial disease affects people of all age. The purpose: According the role of zinc in insulin function and studies on how the SLC30A8 gene expression as a risk factor for type T2DM. The expression of this gene and IAA, C-pepdite, Anti GAP in Diabetics 1 and 2 were conducted.Method: 60 patients withT1DM divided as follows: group of 30 people aged less than 20 years and 30 people aged upper 20 years at the time of diagnosis. 45 patients with type 2 diabetes and 45 healthy persons were selected as control group. To measure the parameters of the IAA and Anti GAD and CPeptide ELISA kit was used. For SLC30A8 gene expression PCR-RFLP method was used.Results : Serum levels of IAA and Anti GAD in patients less than 20 years have increased significantly compared to the other groups. Also in patients with type 1 diabetes ratio type 2 was significantly lower than the amount of C- peptide. Although the SLC30A8 gene expression was reduced in type 1 diabetes than type 2 diabetes. But this difference was not significant among the three groups.Conclusion: The findings of this study and comparing it with previous studies indicating reduced gene expression as SLC30A8 polymorphisms in (T1DM) is ZnT8. To prove definitive role of this gene in the pathogenesis of diabetes, repeat the study with a large sample sizes and in different locations is recommended. |
| کلمات کلیدی | Diabetes, SLC30A8, IAA, C-Peptide, Anti GAD |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| A.pdf | 1396/02/20 | 108831 | دانلود |
| B.pdf | 1396/02/20 | 108024 | دانلود |
| A-10-2886-1.pdf | 1396/02/03 | 143364 | دانلود |
| A-10-2886-1.pdf | 1396/02/03 | 143364 | دانلود |
