Genetic alterations in B-acute lymphoblastic leukemia
Genetic alterations in B-acute lymphoblastic leukemia
نویسندگان: داریوش محمدنژاد , سیده مومنه محمدی , حجت اله نوزاد چروده
کلمات کلیدی: Genetic alterations
Leukemia
Signal transduction
Review
نشریه: , 1 , 48 , 2017
| نویسنده ثبت کننده مقاله |
حجت اله نوزاد چروده |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز سلولهای بنیادی |
| کد مقاله |
60513 |
| عنوان فارسی مقاله |
Genetic alterations in B-acute lymphoblastic leukemia |
| عنوان لاتین مقاله |
Genetic alterations in B-acute lymphoblastic leukemia |
| ناشر |
3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
Acta Haematologica Polonica |
| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://www.sciencedirect.com/science/article/pii/S0001581416301414 |
| Considerable advances have been made in treatment of acute lymphoblastic leukemia
(ALL) with an overall survival rate of 85% in children, and with a great improvement in
adults. Despite this improvements and the accessibility of hematopoietic stem cell transplantation,
relapsed ALL remains a leading cause of childhood mortality emphasizing the
need of new approaches on therapy. Understanding of the pathobiology and genetic
alteration of ALL has been enhanced by developing molecular technologies including
microarray analysis and genome sequencing. These studies have helped identifying
mutations in key signaling pathways and revolutionized the treatment of ALL by drugs
which specifically target the genetic defects of leukemia cells, such as tyrosine kinase
inhibitors. In this paper, we review the clinically important Genetic Alterations in ALL. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Paper, genetic alternation.pdf | 1396/01/30 | 606889 | دانلود |