چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | ناصر رزم آرای ایرانق |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60482 |
| عنوان فارسی مقاله | پیشگیری از عوارض قلبی دوکسوروبیسین در رت با درمان کروسین |
| عنوان لاتین مقاله | Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S002432051630368X |
| Doxorubicin (DOX)-induced cardiotoxicity is well-known as a serious complication of chemotherapy in patients with cancer. It is unknownwhether crocin (CRO),main component of Crocus sativus L. (Saffron), could reduce the severity of DOX-induced cardiotoxicity. Therefore, this study was undertaken to assess the protective impact of CRO on DOX-induced cardiotoxicity in rats. The rats were divided into four groups: control, DOX (2 mg/kg/ 48 h, for 12 days), and CRO groups that receiving DOX as in group 2 and CRO (20 and 40 mg/kg/24 h, for 20 days) starting 4 days prior to first DOX injection and throughout the study. Echocardiographic, electrocardiographic and hemodynamic studies, along with histopathological examination and MTT test were carried out. Our findings demonstrate that DOX resulted in cardiotoxicity manifested by decreased the left ventricular (LV) systolic and diastolic pressures, rate of rise/drop of LV pressure, ejection fraction, fractional shortening and contractility index, as compared to control group. In addition, histopathological analysis of heart confirmed adverse structural changes inmyocardial cells following DOX administration. The results also showed that CRO treatment significantly improved DOX-induced heart damage, structural changes in the myocardium and ventricular function. In addition, CRO did not affect the in vitro antitumor activity of DOX. Taken together, our data confirm that CRO is protective against cardiovascular-related disorders produced by DOX, and clinical studies are needed to examine these findings in human. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناصر رزم آرای ایرانق | اول |
| حسین بابائی | دوم |
| علیرضا محجل نائبی | سوم |
| غلامرضا اسدنسب | چهارم |
| جواد اشرفی | پنجم |
| یدالله آذرمی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Name of barghozideghan TBZMED.JPG | 1396/01/26 | 306568 | دانلود |
| Crocin.pdf | 1396/01/26 | 1223491 | دانلود |
