چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد حسن زاده محله |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60448 |
| عنوان فارسی مقاله | Electrochemical sensing of doxorubicin in unprocessed whole blood, cell lysate, and human plasma samples using thin film of poly-arginine modified glassy carbon electrode |
| عنوان لاتین مقاله | Electrochemical sensing of doxorubicin in unprocessed whole blood, cell lysate, and human plasma samples using thin film of poly-arginine modified glassy carbon electrode |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | Materials Science and Engineering: C |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S0928493116324080 |
| A thin film of poly-arginine fabricated on glassy carbon electrode by one step electrodeposition method is applied for detection of doxorubicin hydrochloride in whole blood, cell lysate, and untreated-plasma samples. Cyclic voltammetry results indicated that the doxorubicin is oxidized via two electrons and two protons at physiological pH (pH = 7.4) using poly-arginine thin film modified glassy carbon. More importantly, electrostatic repulsion takes place between the prepared polymer film-modified electrode and selected drug resulting in the signal amplification on oxidation of doxorubicin and lowering its over potential and thereby selective detection of doxorubicin in real samples. The apparent electron transfer rate constant and transfer coefficient were determined by cyclic voltammetry and were approximately 10.1 s− 1 and 0.82, respectively. Also, using differential-pulse voltammetric technique for sensitive detection of doxorubicin in whole blood and plasma samples, the lower limit of quantification was 69 nM and 103 nM, respectively. Also, application of this amino acid based biocompatible polymeric electrode was tested to the determination of doxorubicin in unprocessed whole blood and the results show that this sensor could be applied in online and real time monitoring of this anti-cancer drug in real samples which is important for clinical research. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد حسن زاده محله | دوم |
| جعفر سلیمانی | اول |
| مرتضی اسکندانی | سوم |
| مریم خوب نسب جعفری | چهارم |
| ابوالقاسم جویبان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 111.pdf | 1396/01/20 | 2816758 | دانلود |
