چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | جلیل پیرایش اسلامیان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 60401 |
| عنوان فارسی مقاله | Targeted superparamagnetic nanoparticles coated with 2-deoxy-D-gloucose and doxorubicin more sensitize breast cancer cells to ionizing radiation |
| عنوان لاتین مقاله | Targeted superparamagnetic nanoparticles coated with 2-deoxy-D-gloucose and doxorubicin more sensitize breast cancer cells to ionizing radiation |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S0960977617304162 |
| Introduction: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. Materials & methods: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 mM doxorubicin and 0.5 mM 2- Deoxy-D-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively. Results: The decreased cell viability with the combined treatment, with determined 42% loading efficiency for 200 ppm 2DG and 93% for5ppm doxorubicin on SPmHANs in PH about 7.4 and 5.5, were calculated to 60.9% and 68% compared to radiotherapy alone inT47D and SKBR3 cells (both with p < 0.05), respectively. Conclusion: Breast cancer cure may boost from The combined targeted nanoparticle treatment with doxorubicin and 2-Deoxy-D-Glucose may boost breast cancer radiotherapy by improved chemodrug localization, increased cytotoxicity in tumor cells and decreased single modality treatment doses. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمدرضا رشیدی شاهگلی | چهارم |
| نگار عیاسی اول | سوم |
| اصغر مصباحی | پنجم |
| محمد محمدزاده | ششم |
| محمد اصغری جعفرآبادی | هفتم |
| جلیل پیرایش اسلامیان | اول |
| میلاد حاتمیان | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Targeted superparamagnetic nanoparticles coated with 2-deoxy-D-gloucose and doxorubicin more sensitize breast cancer cells to ionizing radiation.pdf | 1396/01/07 | 929440 | دانلود |
