چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خسرو ادیب کیا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 60370 |
| عنوان فارسی مقاله | Application of Dry Milling in the Preparation of Amorphous Ezetimibe/Polyvinylpyrrolidone-K30 Dispersions |
| عنوان لاتین مقاله | Application of Dry Milling in the Preparation of Amorphous Ezetimibe/Polyvinylpyrrolidone-K30 Dispersions |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://latamjpharm.org/last.php |
| In the present study, polyvinylpyrrolidone-K30 along with dry milling approach was applied to improve the dissolution rate of ezetimibe, as a practically water-insoluble lipid lowering agent. The comilled formulations were prepared using different drug: polymer ratios and subjected to the milling process under different rotation speeds (100 & 400 rpm) and time durations (1 h & 3 h). The prepared samples were characterized before and after milling process. SEM results showed that the dry milling process considerably reduced the particle size to submicron ranges. Solid state analysis (DSC and PXRD) revealed that an increase in polymer ratio along with milling rotation speed resulted in the conversion of crystalline drug to an amorphous form. According to FTIR study, there was no detectable interaction between the drug and polymer during the process. The results denoted that the particle size reduction as well as drug amorphization during the co-milling process, provided remarkable improvement in dissolution performance of the prepared formulations. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خسرو ادیب کیا | اول |
| ثنا ثقاخانه | دوم |
| محمد برزگر جلالی | سوم |
| حامد همیشه کار | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Application of Dry Milling in the Preparation of Amorphous Ezetimibe PVP k30.pdf | 1395/12/25 | 497897 | دانلود |
