| Abstract The effectiveness of internet-based programs in
prevention and treatment of metabolic syndrome has not been
fully explored. In the present study, we investigate the effect of
a 6-month web-based interactive lifestyle modification program
on anthropometric variables and biochemical risk factors
of cardiovascular disease. The study had been carried out
among 160 patients with metabolic syndrome (intervention,
n=80; control, n=80). The primary outcomes were change in
anthropometric variables, fasting serum glucose (FSG), lipid
profile, insulin sensitivity, and serum adiponectin concentrations
in intervention and control groups. Significant reductions
in anthropometric variables and serum lipids were observed
in both intervention and control groups; however, reduction
in waist-to-hip ratio (WHR), total cholesterol (TC),
and low-density lipoprotein cholesterol (LDL-C) was only
significant in intervention group (P<0.05). Reduction in anthropometric
variables and serum triglyceride, systolic and
diastolic blood pressure, and liver enzymes were significant
in intervention and control groups (P<0.05) but in women
decrease in FSG, TC, and LDL-C were only significant in
intervention group (P<0.05). The present study showed that
a web-based intervention was effective in weight loss and
improving cardio-metabolic factors in patients with metabolic
syndrome after a 6-month intervention |