Association of UCP2 –866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran
Association of UCP2 –866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran
نویسندگان: مهدیه عباسعلیزاد فرهنگی , صفر فرج نیا , محمد اصغری جعفرآبادی
کلمات کلیدی: uncoupling protein 2 (UCP2) gene, –866G>A polymorphism,
nonalcoholic fatty liver disease (NAFLD), anthropometric indices,
biochemical parameters
نشریه: 22592 , 1 , 48 , 2017
| نویسنده ثبت کننده مقاله |
مهدیه عباسعلیزاد فرهنگی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات علوم تغذیه |
| کد مقاله |
60221 |
| عنوان فارسی مقاله |
Association of UCP2 –866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran |
| عنوان لاتین مقاله |
Association of UCP2 –866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
https://www.ncbi.nlm.nih.gov/pubmed/27794526 |
| Objective: To investigate the association of uncoupling protein-2 (UCP2)
–866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver
disease (NAFLD).
Methods: We performed a case-control study with a cohort of 75
patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of
Iranian ethnicity. The UCP2 –866G>A polymorphism (rs659366) was
determined using polymerase chain reaction–restriction fragment length
polymorphism (PCR-RFLP).
Results: Patients with AA and AG genotypes were 71% and 68%,
respectively, more likely to have NAFLD, compared with individuals
with the GG genotype (reference group). In subjects with a GG
genotype, serum triglyceride (TG) concentration was significantly higher
in patients with NAFLD (P¼.04). Serum alanine aminotransferase
(ALT) concentrations in all 3 genotypes and serum aspartate
aminotransferase (AST) concentrations in AG and GG genotypes of
UCP2 gene polymorphism were significantly higher in patients (P
<.05).
Conclusion: Our results revealed a modest modifier effect of –866G>A
UCP2 polymorphism in patients with NAFLD. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| UCP-NAFLD.pdf | 1395/12/13 | 167425 | دانلود |
| Taahod Katbi.jpg | 1395/12/18 | 458010 | دانلود |