چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | احد بازمانی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 60177 |
| عنوان فارسی مقاله | Polymorphisms in Beta-2 Adrenergic Receptor Gene and Association with Tuberculosis |
| عنوان لاتین مقاله | Polymorphisms in Beta-2 Adrenergic Receptor Gene and Association with Tuberculosis |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://link.springer.com/journal/408/195/1/page/1 |
| PurposeGenetic susceptibility for tuberculosis in human has been previously demonstrated. Polymorphisms in genes involved in immune responses may alter the susceptibility of individuals to tuberculosis. Polymorphisms of beta-2 adrenergic receptor(ADRB2) gene can be possibly an important risk factor in tuberculosis. In this study, the association between rs1042713 (Arg16Gly?46A[G) and rs1042714 (Gln27Glu ?79C[G) polymorphisms in ADRB2gene and tuberculosis was evaluated. MethodsGenotype distributions of the rs1042713 (Arg16-Gly?46A[G) and rs1042714 (Gln27Glu?79C[G) polymorphisms inADRB2gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR– RFLP method in an Iranian population. ResultsThe frequency of rs1042713*G and rs1042714*G alleles in ADRB2gene in tuberculosis patients was significantly different from healthy controls [odds ratio (OR) 0.176, 95% confidence interval (CI) 0.065–0.48, P value\0.001 and OR 0.45, 95% CI 0.247–0.825, Pvalue=0.009, respectively]. There were no significant differences in haplotype analysis between the patients and control subjects. ConclusionThe association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2gene makes people more susceptible to develop the disease. |
| نویسنده | نفر چندم مقاله |
|---|---|
| احد بازمانی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| art%3A10.1007%2Fs00408-016-9968-y.pdf | 1395/12/09 | 313507 | دانلود |
