چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ندا دولت خواه | اول |
| فاطمه عباسعلیزاده | سوم |
| ناصر آقا محمد زاده | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: Gestational diabetes mellitus(GDM) is a metabolic condition quite common in pregnancy through which the pregnant woman has high serum glucose levels during her gestation(1). Existing therapies have variable success in reducing short-term complications of gestational diabetes and probably had no effect on its long-term ones(2). The effects of probiotics on blood pressure in hypertensive subjects(3) and in experimental models of hypertension(4, 5) have been investigated. However, randomized clinical trial studies could hardly be traced investigating effect of probiotics taken after diagnosis of GDM (6). By means of this study, we aimed to evaluate the aforementioned health effects of probiotic supplementation on blood pressure in Iranian women with GDM. Main body: A total of 64 Iranian pregnant women, singleton primigravida, at their 24-28 weeks of pregnancy synchronous to the diagnosis of GDM were recruited in the study and were randomly assigned to receive either probiotic supplements (n=32) or the placebo (n=32) for 8 weeks. The probiotic supplement consisted of 4 viable and strains: L.acidophilus LA-5, bifidobacteria B. animalis BB-12, S. thermophilus STY-31 and L.bulgaricus LBY-27 with a total of min 4*109 c.f.u.. Participants blood pressure were measured using a mercury sphygmomanometer Riester, model Diplomat with accuracy of + -3 mm Hg after 15 min resting at each visit (baseline and every 2 week through the study)(7). Data were analyzed using SPSS statistical software package version 22. Mean response scales measured over the 8-week study period were analyzed using appropriate statistical methods. More details of methodology of the whole study and energy intake analysis is to be published elsewhere(8). A p-value below 0.05 was considered as statistically significant. The Clinical trial was registered in the Iranian Registry of Clinical Trials under the number IRCT201405181597N3 accessible through world health organization database of clinical trial registries. At the end of the study, data of the 56 participants (placebo group, n=27; probiotic group, n=29) were analyzed. Mean age of patients was 27.3 (SD: 5.8) years old. The baseline levels of the systolic and diastolic blood pressure. were similar between the groups. The findings of systolic blood pressures of participants didn’t show any signifficant differences between two groups of study, however, diastolic blood pressure in women in the probiotic group was significantly lower than the placebo group after 4 weeks of intervention [66.21±6.36 vs. 69.44±8.35 mmHg, p=0.04 in 4th week of study, 62.41±4.93 vs. 70.74±9.16 mmHg, p<0.01 in 6th week of study and 60.69±5.29 vs. 71.30±10.61 mmHg, p<0.01 in 8th week of study, respectively). Conclusion: In recent years, the health benefits of probiotics have attracted increased attention. Probiotics are defined as live microorganisms that may have health benefits for the host if consumed in adequate amounts(9). We have found in this study that the probiotic supplement containing Lactobacillus acidophilus LA- 5, Bifidobacterium BB-12, Streptococcus Thermophilus STY-31 and Lactobacillus delbrueckii bulgaricus LBY-2 appears to improve diastolic blood pressure in women with GDM. In a study, fermented soy milk probiotic cocktail (L. casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, S. thermophilus, and Bifidobacterium longum) positively reduced SBP in rats after 8 weeks of oral application(10) The therapeutic potential and antimicrobial spectra of probiotics is a complex and a multifactorial process which involves the production of organic acids, hydrogen peroxide(11, 12), bacteriocins, bacteriocin-like inhibitory substances(13, 14), short-chain fatty acids (SCFAs), conjugated linoleic acid (CLA), and γ-amino butyric acid (GABA)(15-17). To the best of our knowledge, the present study was first to evaluate effects of probiotics in blood pressure patients with GDM. However, species differences may be responsible for this finding. Our recommendation for future researchers is to control for confounders such as salt intake and using fermented foods as much as they can and use markers to evaluate patients’ compliance, stool sampling as a detector of bacteria load. |
| کلمات کلیدی | Probiotics ; Gestational Diabetes Mellitus ; Blood Pressure |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| probiotic.jpg | 1395/12/16 | 345945 | دانلود |
| blood pressure nutrition congress.docx | 1395/12/16 | 13696 | دانلود |
