چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سید حسین راستا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 60139 |
| عنوان فارسی مقاله | A novel strategy for low level laser-induced plasmonic photothermal therapy: the efficient bactericidal effect of biocompatible AuNPs@(PNIPAAM-co-PDMAEMA, PLGA and chitosan)† |
| عنوان لاتین مقاله | A novel strategy for low level laser-induced plasmonic photothermal therapy: the efficient bactericidal effect of biocompatible AuNPs@(PNIPAAM-co-PDMAEMA, PLGA and chitosan)† |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | www.rsc.org/advances |
| Nowadays the control of multidrug resistant (MDR) and pandrug resistant (PDR) bacteria has been the subject of extensive research. In this study an effective strategywas developed to destroy bacteria using low-level laser photothermal therapy combined with biocompatible surface-modified AuNPs. First, chitosan, poly(Nisopropylacrylamide)- co-(2-dimethylamino ethyl methacrylate) P(NIPAAM-co-DMAEMA) and poly(lactic-coglycolic acid) (PLGA) modified AuNPs were synthesized and fully characterized. Afterwards, P. aeruginosa and A. baumannii (Two Gram-negative strains of bacteria) were exposed to different doses of low level NIR laser (810 nm) radiation in the presence or absence of the as-prepared surface-modified AuNPs (in a 1 : 1 ratio) and the killing efficiency of the radiated laser doses was calculated based on pour-plate colony count for each condition. Chitosan, P(NIPAAM-co-DMAEMA) and PLGA modified AuNPs were synthesized with a core/shell size of 108, 10 and 120 nm, respectively which was confirmed with DLS and TEM studies. Successful polymerization and surface coating of AuNPs was confirmed by FT-IR and 1H NMR. A decreasing trend in the viability of both bacteria was observed along with an increase of the laser dose for all three types of polymer-coated AuNPs. PLGA@AuNPs exhibited the most effective NIR-induced photothermal killing on both bacteria. In other words, 10 J cm2 and 30 J cm2 doses were enough to destroy almost all P. aeruginosa, and A. baumannii, respectively. Our study suggests the usefulness of lowlevel laser in plasmonic photothermal treatment. The suggested strategy, as a new method of anti-bacterial intervention, can be used for the eradication of infections such as wound infections in order to accelerate the healing process. In addition, the offered strategy can be suggested in the treatment of other bio-threats such as cancerous diseases in vivo |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | هفتم |
| سودابه داوران | ششم |
| سید حسین راستا | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2016 Rasta-Ghratapeh RSC c6ra23213b.pdf | 1395/12/04 | 3505158 | دانلود |
