چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مهناز طبیبی اذر |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده تغذیه |
| کد مقاله | 59981 |
| عنوان فارسی مقاله | ectin-zinc-chitosan-polyethylene glycol colloidal nano-suspensionas a food grade carrier for colon targeted delivery of resveratrol |
| عنوان لاتین مقاله | Pectin-zinc-chitosan-polyethylene glycol colloidal nano-suspensionas a food grade carrier for colon targeted delivery of resveratrol |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S014181301630798X |
| The aimof the present study was to develop chitosan-zinc-pectinate-polyethylene glycol (PEG) nanoparticles (NPs) for colon-targeted delivery of resveratrol.The effects of pectin:ZnCl2:chitosan(PZnC) %w/v, pH and ionic strength of media,and addition of PEG on the colloidal stability and release behavior of resveratrol from NPswere examined byZeta potential, particle size analyzer,scanning electron microscopy (SEM),and Fourier transform-infrared(FTIR)methods.Theparticle size and Zeta potential of PZnCNPs in the ratio of 10:1:3 % w/v were399±18 nm and+25±1 mV,respectively. The addition of PEG to system as a solvent for resveratrol (10%w/v) noticeably decreased the size of NPsto approximately 83±4nm.More than 63% of the resveratrol was encapsulated into the developed NPs; furthermore,a low amount of resveratrol was released duration of one month, using simulated juice model (pH=4) as investigated by High Performance Liquid Chromatography (HPLC) analysis of resveratrol.The remaining resveratrol in NPs (~ 49%) was released in simulated colon fluid in the presence of pectinase. Thissystem can be introduced as a novel platformforsuccessful colon delivery of resveratrolin fruit juice matrix. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهناز طبیبی اذر | دوم |
| حامد همیشه کار | چهارم |
| هاشم اندیشمند | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S014181301630798X-main.pdf | 1395/11/14 | 1868183 | دانلود |
