چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد نوری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | سلامت باروری زنان |
| کد مقاله | 59634 |
| عنوان فارسی مقاله | Follicular fluid PlGF/sFlt-1 ratio and soluble receptor for advanced glycation end–products correlate with ovarian sensitivity index in women undergoing ART |
| عنوان لاتین مقاله | Follicular fluid PlGF/sFlt-1 ratio and soluble receptor for advanced glycation end–products correlate with ovarian sensitivity index in women undergoing ART |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://link.springer.com/article/10.1007/s40618-016-0550-5 |
| Purpose Considering potential roles of soluble receptor for advanced glycation end products (sRAGE) and placental growth factor (PlGF) in ovarian function and embryo implantation, in the present study we have evaluated the association of these factors and also PlGF/sFlt-1 ratio with the ovarian response and implantation rate by dividing patients according to the OSI. Methods In a cross-sectional study, 90 infertile women who were undergoing ICSI cycle using long protocol were recruited. The patients were divided according to ovarian sensitivity index (OSI). ICSI cycle outcomes were evaluated for each patient and PlGF, sFlt-1 and sRAGE levels of follicular fluid were assayed using commercial ELISA kits. Results Follicular fluid (FF) sRAGE levels and PlGF/sFlt-1 ratio were statistically greater in high-responder women than other responders (p < 0.05). Positive correlations were obtained between sRAGE level with the number of oocytes, follicles and OSI level. sRAGE levels with cutoff value of 4.83 (ng/ml) for evaluating the pregnancy outcome showed 81.8 % sensitivity and 60.7 % specificity. Furthermore, there were positive associations between PlGF/sFlt-1 ratio with the number of oocytes, embryos and OSI level. Conclusion In conclusion, the results of current study supported that good ovarian response is independent of pregnancy outcome. Our results showed that FF levels of sRAGE and PlGF/sFlt-1 ratio could be used as markers for determining the high-responder women. Also, FF sRAGE levels could be a good predictor for ART outcome |
| نویسنده | نفر چندم مقاله |
|---|---|
| علی مطاع | دوم |
| لعیا فرزدی | سوم |
| مرتضی قوجازاده | چهارم |
| امیر فتاحی | پنجم |
| کبری حمدی | ششم |
| محمد نوری | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| nejabati paper.pdf | 1395/10/01 | 515802 | دانلود |
