| Introduction. Patients with chronic kidney disease (CKD) face with
uremic toxins. Lactulose could reduce serum urea and creatinine
levels and have some effects on lipid profile and bone minerals.
The aim of this study was to evaluate effect of lactulose on serum
levels of biochemical products in patients with CKD.
Materials and Methods. In this prospective study, 40 patients
with stages 3 and 4 of CKD (52.5% men; mean age, 57.5 ± 12.5
years) were evaluated. All patients received lactulose, 30 mL, 3
times per day for 2 months. Blood samples from all participants
were collected before and at the end of intervention to examine
changes in biochemical parameters, including sodium, potassium,
hemoglobin, urea, creatinine, uric acid, leukocyte and platelets
count, β2-microglobin, and intact parathyroid hormone.
Results. Lactulose significantly decreased urea levels from
70.35 ± 28.00 mg/dL to 64.50 ± 23.51 mg/dL (P = .04), creatinine
levels from 4.04 ± 1.78 mg/dL to 3.45 ± 1.39 mg/dL (P < .001), uric
acid levels from 7.31 ± 1.49 mg/dL to 6.71 ± 1.42 mg/dL (P < .001),
and β2-microglobin levels from 3.25 ± 0.44 mg/L to 3.08 ± 0.33
mg/L (P = .001). The decrease in serum electrolytes, lipid profile,
and intact parathyroid hormone levels were not significant.
Conclusions. Lactulose administration in CKD patients could
decrease levels of various deleterious elements, especially nitrogen
products, and its daily use can be recommended in these patients. |