| Despite using lots of progression in hypersensitivity, it is not yet a cure. Current treatment for allergy
focuses on two approaches, including treats only the symptoms of allergy by utilizing drugs and the
other is desensitization therapy (immunotherapy), which involves administration of specific allergens. The
main obstacle to hypersensitivity permanent treatment is the IgE producing subclass of B-lymphocytes
which is the source of IgE- producing in hypersensitive patients. Removal of these lymphocytes causes
noticeable reduction in the levels of IgE and allergic responses significantly. In this paper, we proposed a
novel complementary approach, which we have called the “nano-liposomes-based target toxicity
machine (NBTTM)”, which controls hypersensitivity by removing the IgE producing B-lymphocytes. In this
regard, our proposed nano-liposomes (pollen allergens/Aptamer/SCFV/MIP loaded lipid bilayer enclosing
toxin interior) will be able to bind to any IgE markers in the lymphatic circulation. The nano-liposomes
will bind to the IgEþatopic B cells and cause cell death by internalizing into B cells. |