چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سیاوش دستمالچی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات بیوتکنولوژی(زیست فناوری) |
| کد مقاله | 59488 |
| عنوان فارسی مقاله | Evaluating retardation and physicochemical properties of co-ground mixture of Na- diclofenac with magnesium stearate |
| عنوان لاتین مقاله | Evaluating retardation and physicochemical properties of co-ground mixture of Na- diclofenac with magnesium stearate |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S0032591011006589 |
| It is suggested here that co-grinding of drug with a hydrophobic carrier has the potential to be optimized for the reduction of drug dissolution rate and thereby production of sustained release systems. In the present study Na-diclofenac was co-ground with magnesium stearate. Various concentrations of magnesium stearate were used to investigate the effect of carrier concentration on drug release. Dissolution test was carried out at pH 7.2 for determining of drug dissolution rate from prepared formulations. The release rate of drug from co-ground samples was compared to that of from physical mixture formulations. X-ray crystallography, DSC and FT-IR were used to investigate the formation of any complex between drug and carrier or any crystallinity changes during the manufacturing process. The results showed that all co-ground samples demonstrated slower release rates than their physical mixture counterparts in the ratios higher than 1:0.5 (drug: carrier). Decreased dissolution rate was observed with increasing of magnesium stearate concentration. This could be due to the presence of more hydrophobic particles, magnesium stearate, around the drug particles at high concentrations. XRPD, DSC and FT-IR studied ruled out any significant interaction between drug and carrier, only a minor crystallinity change was observed during the process. Kinetically, release pattern of drug fitted best to Higuchi model. Then co-grinding of water soluble drugs such as Na-diclofenac with hydrophobic carrier such as magnesium stearate could be used as an appropriate approach to retard drug release and thereby production of sustained release systems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیاوش دستمالچی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| article_1031_be0d6c7c33f37b85bbbce5918cbbdd88.pdf | 1395/09/16 | 617022 | دانلود |
