بررسی عوامل خطر پیشرفت بیماری آرتریت روماتوئید در زنان مبتلا در شمالغرب ایران: یک مطالعه مورد- شاهدی
Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study
نویسندگان: ندا قمرزاد شیشوان , سعید پیروزپناه , مهرزاد حاج علیلوی بناب , علیرضا خبازی اسکویی , الهام میرطاهری , نازیلا فرین , زهرا شکیبای نوین
کلمات کلیدی: Rheumatoid Arthritis; Breast-Feeding; Reproductive History; Oral Contraceptives
نشریه: 16618 , 12 , 18 , 2016
| نویسنده ثبت کننده مقاله |
سعید پیروزپناه |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده تغذیه |
| کد مقاله |
59442 |
| عنوان فارسی مقاله |
بررسی عوامل خطر پیشرفت بیماری آرتریت روماتوئید در زنان مبتلا در شمالغرب ایران: یک مطالعه مورد- شاهدی |
| عنوان لاتین مقاله |
Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study |
| ناشر |
11 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://ircmj.com/26874.abstract?page=article&article_id=26874 |
| Background: Given the high prevalence of rheumatoid arthritis (RA) in females of reproductive ages, it seems that hormonal factors might be important in RA pathogenesis.
Objectives: The current study aimed to investigate the association between females’ reproductive factors occurring prior to the onset of rheumatoid arthritis and the risk of RA development.
Methods: This case-control study was conducted on 231 patients with RA and 238 controls among females aged 26 - 64 years old from the North-West of Iran. The adjusted risk of RA was assessed using multivariate logistic regression models.
Results: Females ≥ 14 years old at menarche, were more likely to be at risk of RA (OR = 1.69; 95%CI: 1.08 - 2.64). Advanced maternal age at first delivery (OR = 1.91; 95%CI: 1.21 - 3.26) and having abortion (OR = 1.97; 95%CI: 1.23 - 2.99) significantly increased the risk of RA. Post-menopausal status increased the risk of developing RA (OR = 2.97; 95%CI: 1.98 - 4.46). Longer duration of breast-feeding was determined as significant protective variable for RA (P < 0.05). Subjects with oral contraceptives (OCs) use (OR = 0.36; 95% CI: 0.20 - 0.64), parity (OR = 0.20; 95%CI: 0.06 - 0.70) or large number of children tended to show rather more reduced risk of RA.
Conclusions: The risk of RA increased with delayed menarche, advanced maternal age at first delivery and early age at menopause. However, longer duration of breast-feeding, parity, large number of children and consumption of OCs were found as protective independent variables against RA. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Iranian Red Crescent Medical Journal - - Kowsar.jpg | 1395/10/04 | 217862 | دانلود |
| ircmj-18-12-26874.pdf | 1395/10/04 | 222224 | دانلود |