چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | جلال عبدالعلیزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ایمونولوژی |
| کد مقاله | 59374 |
| عنوان فارسی مقاله | The Study of Extracellular Protein Fractions of Probiotic Candidate Bacteria on Cancerous Cell Line |
| عنوان لاتین مقاله | The Study of Extracellular Protein Fractions of Probiotic Candidate Bacteria on Cancerous Cell Line |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.aimjournal.ir/Home.aspx |
| Introduction: spite of many reports about the anticancer effect of these bacteria in in–vivo and in–vitro, their mechanisms of action are not completely understood. The goal of this study was to compare the extracellular fractions of Lactobacillus casei and L. paracasei on the anti proliferation and apoptosis induction in K562 cell line. Materials and Methods: L. casei and L. paracasei were cultured in MRS broth medium. Then extracellular secretions were collected column, and the anticancer properties were evaluated. Results: The results of SDS–PAGE showed various molecular weight of fractionated proteins of L. casei and L. paracasei. Bioactivity assessment illustrated that anti proliferative effects on K562 cells is dose and time dependent and the cytotoxic effects was parallel with protein concentration and the increase of time from 36 to 72 hours. Conclusion: Regarding the cell cytotoxicity results, the fractionated extracellular proteins of L. casei and L. paracasei effects in inhibition of cancer cell proliferation. However, more study is needed to better elucidate the mechanisms of extracted proteins, and its effect on other human cancer cell lines. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علی اکبر موثق پور اکبری | چهارم |
| جلال عبدالعلیزاده | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The Study of Extracellular Protein Fractions of Probiotic.pdf | 1395/08/26 | 708200 | دانلود |
