چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| ABSTRACT Background and aims: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology. The erosive (ulcerative) form of OLP is particularly known as a premalignant disease. However, a complete cure has not been found for this condition. Mycophenolate mofetil (MMF) is a new drug that seems to be effective in improving OLP lesions. In dermatology, success of oral MMF has been reported in case and pilot studies in the treatment of pemphigus and pemphigoid lesions, Crohn’s disease, psoriasis, lupus erythematosus and cutaneous erosive lichen planus. But there are no studies on the efficacy of mucoadhesive form of MMF in ulcerative OLP. Therefore, this study was performed to determine the therapeutic effect of MMF mucoadhesive on ulcer size and severity of burning sensation and pain of OLP lesions in patients. Methods: In this clinical trial study, 27 patients with OLP, referred to Oral Medicine Department of Tabriz Dental School, were enrolled. Ten patients who had bilateral ulcerative lesions of OLP were enrolled in a double-blind clinical trial (group A); 17 patients who had unilateral ulcerative OLP lesions were enrolled in a before-after clinical trial (group B). In group A, the patients were instructed to place 2% MMF mucoadhesive on one of the dried lesions and place a placebo on the other one twice daily for 4 weeks. In group B, the patients only used 2% MMF mucoadhesive in the same manner. Lesion sizes were measured by a digital caliper and the severity of burning sensation and pain by VAS (visual analog scale) at baseline and each week of the treatment. Data were analyzed with paired t-test using SPSS 16. Results: In group A, at the end of the treatment (week 4), there were significant reductions in pain and burning sensation severities (P=0.012) and lesion sizes decreased (P=0.004) on case sides; in addition, pain and burning sensation severity decreased on control sides (P=0.048). However, the differences in lesion sizes on control sides were not significant (P=0.216). In group B, at week 4, there were significant reductions in pain and burning sensation severity P=0.004) and lesion sizes decreased (P=0.002). There were no significant differences in burning sensation and lesion size decreases at weeks 1, 2 and 3 in both groups. No side effects were reported by the patients. Conclusion: Based on the results, 2% MMF mucoadhesive was effective in decreasing burning sensation and pain severity and ulcer size of ulcerative OLP and the effect was time-dependent. Keywords: Ulcerative Oral Lichen Planus, Mycophenolate Mofetil, Mucoadhesive, Burning sensation and Pain. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علی تقوی زنوز | اول |
| معصومه مهدی پور | دوم |
| جواد شکری | سوم |
| مرضیه آقازاده | پنجم |
| نرگس قلیزاده | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Mycophenolate1.pdf | 1395/08/12 | 474181 | دانلود |
