Role of Probiotics in managing of Helicobacter Pylori infections: A Review

Role of Probiotics in managing of Helicobacter Pylori infections: A Review


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دانشگاه علوم پزشکی تبریز
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نویسندگان: ابوالفضل اکبرزاده , عباس مجدی سقین سرا , محمد پورحسن مقدم , حمید طایفی نصرآبادی , مرتضی میلانی

کلمات کلیدی: Helicobacter pylor probiotics gastroprotection immune response

نشریه: 0 , 2016 , 06 , 2016

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نویسنده ثبت کننده مقاله عباس مجدی سقین سرا
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه دانشکده پزشکی
کد مقاله 59182
عنوان فارسی مقاله Role of Probiotics in managing of Helicobacter Pylori infections: A Review
عنوان لاتین مقاله Role of Probiotics in managing of Helicobacter Pylori infections: A Review
ناشر 6
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق) Drug Research
نوع مقاله Review Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت Drugres/2016-06-1226/27/10/2016/MPS

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Background: Helicobacter pylori is a prevalent pathogen which is considered as an etiological cause for gastroduodenal ulcers, and a substan-tial risk factor for gastric malignancies. The vital factor to take into account is that roughly half of the world’s population is infected with this bacterium. However, most subjects colonized remain asymptomatic and do not require any treatment. Several antimicrobial agents such as amoxicillin, clarithromycin and metronidazole are used to eradicate the infection. However, these drug regiments do not eradicate H. pylori in all patients because of the anti-drug resistance. Aim: In this review we aim to discuss the role and mechanisms of probiotics, as supportive medicines, in management of H. pylori infection. Methods: We have reviewed the published articles in PubMed and Medline databases. Also, abstracts presented in international confer-ences on the management of H. pylori infections and treatment protocol, have been thoroughly reviewed. Results: The overall trend in the literature indi-cates the usefulness of probiotics in controlling H. pylori infection. This bacterium is among the most studied human pathogens regarding the efficacy of probiotics for treating its infection. Nevertheless, some studies suggest that probiot-ics do not efficiently eradicate H. pylori but retain the number of this bacterium at low levels inside the human stomach. Conclusion: The analyzed literature suggest that when probiotics are consumed in conjunc-tion with antibiotics, the eradication rate may be improved through modulating the immune response and decreasing the adverse effects of routine drugs leading to gastroprotection

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نویسنده نفر چندم مقاله
ابوالفضل اکبرزادهدوم
عباس مجدی سقین سراسوم
محمد پورحسن مقدمچهارم
حمید طایفی نصرآبادیپنجم
مرتضی میلانیششم

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