چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مسعود دارابی امین |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | تیم های تحقیقاتی دانشگاه |
| کد مقاله | 59148 |
| عنوان فارسی مقاله | Correlation of secretory phospholipase-A2 activity and fatty acids in cerebrospinal fluid with liver enzymes tests |
| عنوان لاتین مقاله | Correlation of secretory phospholipase-A2 activity and fatty acids in cerebrospinal fluid with liver enzymes tests |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | Journal of Analytical Research in Clinical Medicine |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح چهار – سایر سایت های تخصصی |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://journals.tbzmed.ac.ir/JARCM/Abstract/JARCM_1950_20150712092837 |
| Introduction: The aim was to determine whether secretory phospholipase-A2 (sPLA2) activity and fatty acids in cerebrospinal fluid (CSF) are correlated with liver enzymes tests. Methods: CSF and serum samples were collected from 49 patients (age 18-65) as part of routine diagnostic testing. Along with serum liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), the fatty acid composition of CSF was measured by gas liquid chromatography. CSF enzyme activities of sPLA2 were measured using the standard assay with diheptanoyl thio-phosphatidylcholin as substrate. Results: The saturated fatty acids (SFAs) including palmitic acid and stearic acid were positively, and the unsaturated fatty acids including oleic acid and linoleic acid were negatively correlated with liver enzymes tests. In regression analysis with adjustment for body mass index (BMI), the elevated liver enzymes tests were positively associated with activity of sPLA2 (β > 0.31, P < 0.050) and total SFAs (β > 0.38, P < 0.010) and negatively with total monounsaturated fatty acids (MUFAs) (β < -0.40, P < 0.001) contents of CSF. Conclusion: CSF activity of sPLA2 and fatty acids may be linked to peripheral markers of liver function, suggesting an indirect impact of central fatty acids on hepatocytes function and metabolism. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر حسین جعفری روحی | دوم |
| علی پاشاپور | سوم |
| مسعود دارابی امین | ششم |
| سیده سپیده قدوسی فر | اول |
| امیر مهدی زاده حقیقی | چهارم |
| مقصود شاکر | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2016 CSF FA JARCM-4-39.pdf | 1395/08/08 | 1391923 | دانلود |
| Journal Information _ JARCM.pdf | 1395/08/08 | 1718085 | دانلود |
