| Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles
(NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustainedrelease
properties, low toxicity, and biocompatibility with tissue and cells. In the present review, the structure
and properties of PLGA copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide
were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography,
Fourier transform infrared spectroscopy and differential scanning calorimetry. Methods of preparation and
characterization, various surface modifications, encapsulation of diverse anticancer drugs, active or passive
tumor targeting and different release mechanisms of PLGA nanoparticles are discussed. Increasing experience in
the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer
treatment, with high efficacy and few side effects. |