چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مجتبی ورشوچی فرد |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 58893 |
| عنوان فارسی مقاله | In vitro susceptibility of Mycobacterium tuberculosis to clarithromycin |
| عنوان لاتین مقاله | In vitro susceptibility of Mycobacterium tuberculosis to clarithromycin |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | سایر موارد |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.academicjournals.org/AJPP |
| This study was done to evaluate in vitro susceptibility ofMycobacterium tuberculosis of clarithromycin. In this prospective study, 90 M. tuberculosis strains (40 resistant strains and 50 susceptible strains) referred to the Tabriz laboratory of TB research Center were selected and cultured in L-J medium and with 3 doses of clarithromycin. 40strains were resistant and 50 strains were sensitive to first line drugs. 60% of strains were resistant to clarithromycin with 20 μg/ml. Significant difference was not found if resistant rate of M. tuberculosis strains to clarithromycin with 20 and 40 μg/ml and all studied strainwas sensitive to clarithromycin with 80 μg/ml. 33 strains of resistant strains and 48 strains of sensitive strains to first anti tuberculosis line drug was sensitive to clarithromycin with 40 μg/ml. Based on the results of this study and other studies, the need for extensive laboratory study and using liquid culture (including Midelbary) and advanced techniques such as BACTEC and even more animal models are necessary. The long-term clinical study using clarithromycin in combination with anti-TB therapy, especially in the case of MDR-TB strains is necessary for the low side effect as clarithromycin in the treatment of tuberculosis, in the form of suitable compounds which can be used as second drug. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مجتبی ورشوچی فرد | اول |
| سید رضا مودب | سوم |
| بهروز نقیلی حکم آبادی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| In vitro susceptibility of Mycobacterium tuberculosis to clarithromycin.pdf | 1395/07/10 | 146832 | دانلود |
