چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | آیلا بهرامیان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده دندانپزشکی |
| کد مقاله | 58835 |
| عنوان فارسی مقاله | Immunohistochemical Evaluation of Ki-67 Expression in Erosive and Non-Erosive Oral Lichen Planus |
| عنوان لاتین مقاله | Immunohistochemical Evaluation of Ki-67 Expression in Erosive and Non-Erosive Oral Lichen Planus |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | Avicenna Journal of Dental Research |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح چهار – ISC - Islamic Science Citation |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | Avicenna Journal of Dental Research. 8(2): e25372 , DOI: 10.17795/ajdr-25372 |
| Background: Oral lichen planus (OLP) is a relativelycommon,chronicinflammatory condition, which is considered a precancerous lesion. The Ki-67 antigen is expressed in all the phases of the cellular cycle in proliferative cells. Different studies have suggested the relationship between incidences of malignancy in precancerous lesions and the occurrence of this protein. Objectives: This study aimed to evaluate Ki-67 expression in erosive and non-erosive oral lichen planus. Materials and Methods: Specimens (formalin-fixed and paraffin-embedded) of 30 lesions of erosive OLP and 30 lesions of nonerosive OLP were referred for immunehistochemistry (IHC) analysis of Ki-67. Results of immunohistochemistry were statistically evaluated by means of the chi-square test and independent t-test. The level of statistical significance was established at P < 0.05. Results: The mean expression of Ki-67 in patients with erosive OLP was higher than people in the control group. These differences were statistically significant (P = 0.041). Conclusions: Since Ki-67 is extensively accepted as an important biomarker in diagnosis, prognosis and treatment of cancerous and precancerous lesions, a high degree of presence of this biomarker in chronic precancerous lesions, such as erosive OLP, can be of great use in prognosis and suggested treatments. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نرگس قلیزاده | اول |
| معصومه مهدی پور | دوم |
| آیلا بهرامیان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ajdr-08-02-25372.pdf | 1395/07/04 | 108171 | دانلود |
