چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | نرگس سیفی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ایمونولوژی |
| کد مقاله | 58827 |
| عنوان فارسی مقاله | مهاجرت سلول های دندرتیکی به غدد لنفاوی و تشدید آن برای برانگیختن پاسخ های ضد توموری |
| عنوان لاتین مقاله | Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Review Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.croh-online.com/article/S1040-8428(16)30210-4/fulltext |
| Better prognoses associated with increased T cell infiltration of tumors, as seen with chimeric antigen receptor (CAR) T cell therapies and immune checkpoint inhibitors, portray the importance and potential of the immune system in controlling tumors. This has rejuvenated the field of cancer immunotherapy leading to an increasing number of immunotherapies developed for cancer patients. Dendritic Cells (DCs) vaccines represent an appealing option for cancer immunotherapy since DCs have the ability to circumvent tolerance to tumors by its adjuvant properties and to induce memory T cells that can become persistent after initial tumor clearance to engage potential metastatic tumors. In the past, DC-based cancer vaccines have elicited only poor clinical response in cancer patients, which can be attributed tocomplex and a multitude of issues associated with generation, implementing, delivery of DC vaccine andtheir potential interaction with effector cells. The current review mainly focuses on migration/traffickingof DCs, as one of the key issues that affect the success of DC-based cancer vaccines, and discusses strategiesto enhance it for cancer immunotherapy. Additionally, impact of maturation, route of DC delivery andnegative effects of tumor microenvironment (TME) on DC homing to LN are reviewed. Moreover, strategiesto increase the expression of genes involved in Lymph node homing, preconditioning of the vaccinationsite, enhancing lymph node ability to attract and receive DCs, while limiting negative impact of TME onDC migration are discussed. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نرگس سیفی زاده | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| PIIS1040842816302104_2.pdf | 1395/07/02 | 1836916 | دانلود |
