چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | کریم شمس اسنجان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 58784 |
| عنوان فارسی مقاله | Induction of Multilineage Markers in Human Myeloma Cells and Their Down-Regulation by Interleukin 6 |
| عنوان لاتین مقاله | Induction of Multilineage Markers in Human Myeloma Cells and Their Down-Regulation by Interleukin 6 |
| ناشر | 8 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.ncbi.nlm.nih.gov/pubmed/17261502 |
| Induction of Multilineage Markers in Human Myeloma Cells and Their Down-Regulation by Interleukin 6 Abstract Human primary myeloma cells are well known to be heterogeneous with regard to morphology and surface phenotype.We confirmed the heterogeneous expression of such multilineage markers as CD33, CD7, CD56, CD4, and CD86 in primary myeloma cells from 20 patients with multiple myeloma and in 8 human myeloma cell lines. CD33 expression in the Liu01 cell line, a subclone of U266 cells, and in vitamin D3–treated ILKM3 cells, correlated with a monocytoid morphology featuring convoluted nuclei and with increased C/EBPa expression.CD56+ myeloma cells from some myeloma patients and the CD56+ (but not the CD56–) myeloma cell lines expressed neuronal cell markers, such as neuron-specific enolase and b-tubulin III. CD7 expression in Liu01 cells and forskolin-stimulated U266 cells coincided with the presence of large cytoplasmic granules, and these cells featured increased expression of perforin messenger RNA and significant natural killer cell activity. Interleukin 6 (IL-6), a growth factor for myeloma cells, down-regulated CD33, CD7, or CD56 expression in primary myeloma cells, as well as in Liu01 cells. Therefore, these data suggest that human myeloma cells are capable of inducing the expression of multilineage markers and that IL-6 can down-regulate such expression. |
| نویسنده | نفر چندم مقاله |
|---|---|
| کریم شمس اسنجان | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Induction of Multilineage Markers in Human Myeloma Cells and Their Down-Regulation by Interleukin 6.pdf | 1395/06/28 | 500948 | دانلود |
