چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | انسیه سیدرضازاده دلالی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات سل و بیماری های ریوی |
| کد مقاله | 58700 |
| عنوان فارسی مقاله | مکمل ویتامین E- سلنیم و پاسخ های بالینی سل ریوی فعال |
| عنوان لاتین مقاله | Vitamin E-Selenium Supplement and Clinical Responses of Active Pulmonary Tuberculosis. |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – PubMed |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.tanaffosjournal.ir/en/archive.php?lrid=425 |
| Vitamin E-Selenium Supplement and Clinical Responses of Active Pulmonary Tuberculosis Background: It has been suggested that some micronutrients have antioxidant and immunomodulating effects on the treatment of mycobacterial disease. In this study, we investigated the effect of vitamin E and selenium supplementation on clinical responses in tuberculosis patients. Materials and Methods: Thirty-five patients with pulmonary tuberculosis diagnosed on the basis of a positive sputum smear for acid fast bacilli or culture for Mycobacterium tuberculosis were selected. Serial sputum examinations were performed before the diagnosis and at the end of every 15 days, during two months of therapy; chest X-ray of all patients were also evaluated. In a setting of double-blind, placebo-controlled trial, the patients were divided into two groups. Group I(n=17) received combination of vitamin E and selenium which composed of 140 mg of α-TE and 200 μg selenium per day, and group II received placebo. All patients in both groups received the same antituberculosis standard therapy. Clinical examination and assessment of micronutrient levels were carried out before and after 2 months of intervention. Results: In group I, elimination of tubercle bacilli from sputum occurred earlier than in group II (6 weeks versus 8 weeks, respectively; p= 0.001). At the end of the 2nd and 6th month of therapy, the median reduction in cavity surface area on chest X-ray in group I was significantly more than group II (2nd month: 1.5(0.0-4.5 versus 9.0(4.0-18.0);p= 0.03, and 6th month: 0.0(0.0-2.3) versus 6.3(1.0-15.8); p<0.05, respectively). Conclusion: Vitamin E plus selenium supplementation may improve the microbiological and radiological outcomes of the treatment in patients with pulmonary tuberculosis. |
| نویسنده | نفر چندم مقاله |
|---|---|
| انسیه سیدرضازاده دلالی | اول |
| علیرضا استاد رحیمی | دوم |
| سلطانعلی محبوب | سوم |
| خلیل انصارین | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tanaffos-Vitamin E-Selenium Supplement and Clinical Responses.pdf | 1395/06/21 | 165535 | دانلود |
