چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | علیرضا خبازی اسکویی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 58659 |
| عنوان فارسی مقاله | IL-27 Gene Polymorphisms in Iranian Patients with Behcet’s Disease |
| عنوان لاتین مقاله | IL-27 Gene Polymorphisms in Iranian Patients with Behcet’s Disease |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – PubMed |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.clin-lab-publications.com |
| Background: Behcet’s Disease (BD) is a chronic systemic inflammatory disease of unknown etiology, principally characterized by relapsing periods of a broad range of clinical symptoms. Cytokines play fundamental roles in the pathogenesis of BD. Polymorphisms within cytokine genes have been found to play a pathogenic role in the development of autoimmune/inflammatory disorders. Interleukin 27 (IL-27), a new pro-/anti-inflammatory cytokine, is a great candidate for chronic inflammatory disease studies. The purpose of this study was to investigate a possible association between polymorphisms in the IL-27 gene and susceptibility to BD. Methods: Fifty Iranian patients with BD and one hundred healthy individuals were examined for rs153109A/G and rs181206T/C IL-27 gene single nucleotide polymorphisms using RFLP-PCR and ARMS-PCR, respectively. Allele and genotype distributions were compared between groups using chi-square or Fisher’s exact test. Results: Frequencies of the rs153109AA genotype and rs153109A allele were statistically higher in BD patients compared with the control group (p = 0.034 and p = 0.011, respectively). The genotype and allele frequencies of rs181206 T/C polymorphism in BD patients were not significantly different from those of healthy controls. Conclusions: Present findings demonstrate for the first time that the IL-27 gene rs153109 A/G SNP may be involved in susceptibility to BD in the Iranian population. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا خبازی اسکویی | چهارم |
| زهره بابالو | دوم |
| ابراهیم سخی نیا | سوم |
| داریوش شانه بندی | پنجم |
| سعید صدیق اعتقاد | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ff.pdf | 1397/12/02 | 238008 | دانلود |
