چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | جلیل پیرایش اسلامیان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 58410 |
| عنوان فارسی مقاله | نانوذرات اکسیداهن سوپرپارامگنتیک هیدروکس اپاتایت حاوی دکسوروبیسین دردرمان سرطان |
| عنوان لاتین مقاله | Doxorubicin loaded large-pore mesoporoushydroxyapatite coated superparamagnetic Fe3O4 nanoparticles for cancer treatment |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | Int J Pharm. 2016 Jul 25;509(1-2):159-67 |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – Medline |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.ncbi.nlm.nih.gov/pubmed/27234695 |
| In the present study, a series of multifunctional drug delivery systems based on mesostructured hydroxyapatite coating and superparamagnetic nanoparticles with pH-responsive characters was prepared. The structure of each new synthesized nanoscale composite was fully characterized by XRD, FTIR,TEM, VSM and BET. The results showed a good ordered mesostructure having large pores, high pore volume,high surface area, and varied super paramagnetic properties. The mesoporous hydroxyapatite coated super paramagnetic Fe3O4 nanoparticles were applied as a drug delivery carrier loaded with doxorubicin(DOX) as a model drug. The storage/release properties of the developed nonocarriers in phosphate buffer saline (PBS) were studied in two certain pHs: pH = 7.4 (the human blood pH) and pH= 5.5 (pH of cancer cells). The large pores in the synthesized mesoporous acted as an excellent carrier for DOX molecules with a loading efficiency of 93% which is much higher than that of the conventional hydroxyapatite particles. When the pH of the release medium (PBS) was changed from 7.4 to 5.5, the drug release increased significantly from 10% of the adsorbed drug to about 70%. DOX-loaded mesostructure hydroxyapatite reduced the viability of SKBR3 and T47D cells by 54.7 and 57.3%, respectively, which were very similar to 56.8 and 60.4% reduction resulted from free DOX incubation. This new drug delivery system which benefits from both super paramagnetic properties and pH-responsive performances may serve as a suitable platform for developing new biocompatible drug carriers and could have a good potential use in targeted cancer therapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جلیل پیرایش اسلامیان | دوم |
| محمدرضا رشیدی شاهگلی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Doxorubicin loaded large-pore mesoporoushydroxyapatite coated superparamagnetic Fe3O4 nanoparticles for cancer treatment.pdf | 1395/05/02 | 1497987 | دانلود |
