چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | وجیهه شیخ علیزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ایمونولوژی |
| کد مقاله | 58349 |
| عنوان فارسی مقاله | بررسی فراوانی ژنهای کدکننده آنزیمهای تغییر دهنده آمینوگلیکوزیدها و armA در Sequence group های مختلف آسینتوباکتر بومانی |
| عنوان لاتین مقاله | Frequency of Aminoglycoside-Modifying Enzymes and ArmA Among Different Sequence Groups of Acinetobacter baumannii in Iran |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://online.liebertpub.com/doi/10.1089/mdr.2015.0254 |
| We evaluated aminoglycoside resistance in 87 Acinetobacter baumannii strains isolated from four hospitals located in the North West region of Iran and typed them in sequence groups (SGs) using trilocus sequence-based scheme to compare their clonal relationships with international clones. Resistance toward aminoglycosides was assayed by minimum inhibitory concentration (MIC) and presence of aminoglycoside-modifying enzymes (AMEs), and ArmA-encoding genes were evaluated in different SGs. The majority of isolates belonged to SG1 (39%), SG2 (33.3%), and SG3 (12.6%), whereas the remaining ones were assigned to six novel variants of SGs. MIC determination revealed netilmicin as the most and kanamycin as the least active aminoglycosides against all groups. Among the varied SGs, isolates of SG2 showed more susceptibility toward all tested aminoglycosides. APH(3′′)-VIa-encoding gene was predominant in SG1 (47%), SG2 (62%), and SG6–9 (100%). However, AAC(3′)-Ia (100%) and ANT(2′)-Ia (90.9%) were the dominant AMEs in SG3. There was significant association between harboring of aminoglycoside resistance genes and specific aminoglycosides: gene encoded by APH(3′)-VIa was allied to resistance against amikacin and kanamycin, whereas ANT(2′)-Ia was related to the resistance toward gentamicin and tobramycin in SG2. In SG1, tobramycin resistance was correlated with harboring of AAC(6′)-Ib. Screening of armA demonstrated the presence of this gene in SG1 (58.8%), SG2 (10.3%), as well as SG3 (9%). Our results revealed definite correlation between the phenotypes and genotypes of aminoglycoside resistance in different clonal lineages of A. baumannii. |
| نویسنده | نفر چندم مقاله |
|---|---|
| آلکا حسنی | اول |
| وجیهه شیخ علیزاده | دوم |
| محمد آهنگرزاده رضایی | سوم |
| محمد رحمتی | چهارم |
| اکبر حسنی | پنجم |
| رضا قوطاسلو | ششم |
| حمید رضا گلی | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| hasani2016.pdf | 1395/04/29 | 167150 | دانلود |
