چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مسعود دارابی امین |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 58305 |
| عنوان فارسی مقاله | Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid |
| عنوان لاتین مقاله | Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | Iranian Biomedical Journal logo |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – Medline |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://ibj.pasteur.ac.ir/browse.php?a_id=1690&sid=1&slc_lang=en |
| Background: Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. Methods: Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administered to the rats with APAP-induced liver damage. The isolated liver cells were infused intraperitoneally into rats. Blood samples were obtained to evaluate the changes in the serum liver enzymes, including activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and the level of serum albumin. To assess the engraftment of infused hepatocytes, rats were euthanized, and the liver DNA was used for PCR using sex-determining region Y (SRY) primers. Results: The levels of AST, ALT and ALP in the serum of rats with APAP-induced liver injury were significantly increased and returned to the levels in control group by day six. The APAP-induced decrease in albumin was significantly improved in rats through cell therapy, when compared with that in the APAP-alone treated rats. SRY PCR analysis showed the presence of the transplanted cells in the liver of transplanted rats. Conclusion: Stearic acid-rich diet in combination with cell therapy accelerates the recovering of hepatic dysfunction in a rat model of liver injury. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسعود دارابی امین | سوم |
| محمد علی اقبال | دوم |
| لیلا روشنگر | چهارم |
| نصرت اله ضرغامی | ششم |
| محمد نوری | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2016 Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid IBJ.pdf | 1395/04/15 | 425721 | دانلود |
| 2016 Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid IBJ pubmed.pdf | 1395/04/15 | 90611 | دانلود |
| Medline index Iranian biomedical journal.pdf | 1395/04/15 | 82336 | دانلود |
