چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد رضا علی پرستی خاصلویی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ایمونولوژی |
| کد مقاله | 58287 |
| عنوان فارسی مقاله | تاثیر گرلین بر نسبت بیان Bax/Bcl-2 در بافت ریه موش صحرایی نگهداری شده در شرایط هیپوکسی مزمن |
| عنوان لاتین مقاله | Effect of Ghrelin on Bax/Bcl-2 Gene Expression Ratio in Lung Tissue of Rats with Chronic Hypoxia |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | JOURNAL OF ZANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.zums.ac.ir/journal/browse.php?mag_id=110&slc_lang=en&sid=1 |
| Background and Objective: Ghrelin has different functions in the body and one of its newly known roles is the antiapoptotic effect. However, this effect of ghrelin has not been considered in the probable hypoxia induced apoptosis in the animal lung tissue. The aim of this study was to examine the effect of ghrelin treatment on Bax/Bcl-2 gene expression in the lung tissue of rats with chronic hypoxia. Materials and Methods: Twenty four male Wistar rats were divided in three experimental groups of normal, hypoxic+saline and hypoxic+ghrelin and were treated for 2 weeks. The expression level of Bax and Bcl-2 genes were assessed using Real-Time PCR in isolated lung tissues of all animals. In addition, histological changes of pulmonary arteries were examined following Hematoxylin-Eosin staining of the isolated tissues. Results: Chronic hypoxia caused pulmonary artery wall thickness and treatment with ghrelin reversed the changes to the normal. Keeping animals under chronic hypoxia treated or not with ghrelin had no significant effect on Bax/Bcl-2 gene expression ratio as measured in the total lung. Conclusion: Ghrelin treatment restores the histological changes induced by chronic hypoxia in rats.However, no significant changes in Bax/Bcl-2 gene expression ratio as a marker of cell apoptosis seem to occur in the isolated lung tissues, even after ghrelin treatment. Further similar studies especially in vascular endothelial and smooth muscle cells are recommended. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد رضا علی پرستی خاصلویی | اول |
| شهره الماسی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ZUMSJournal-v24n106p79-fa[1].pdf | 1395/04/13 | 288647 | دانلود |
